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Cocaine withdrawal is characterized by serotonin depletion throughout the brain and decreased levels of 5HT in the nucleus accumbens [ 39]. The European study ( n = 189) compared six degarelix treatment groups with starting doses of 200 or 240 mg followed by maintenance doses of 80, 120, or 160 mg. Alternative therapies that do not inhibit the CYP3A4 isoenzyme should be considered http://www.italia-farmacia.com/. The results of the meta-analysis are shown in Table The pooling of results for this meta-analysis could lead to bias because nonsignificant findings may not have been included.